Note: The following content is for general information only and does not replace the advice of professional doctors, pharmacists or other medical professionals. If you or others are at risk of self-harm or suicide, please seek professional help immediately or call the local emergency number. Regarding the issue that drug combinations may increase the risk of self-harm, research and clinical observations have shown that some drugs or drug combinations may increase the risk of self-harm in certain populations (such as mood disorders, impulse control disorders or people of special age groups) due to their effects on the central nervous system and mood regulation. The following types of drug combinations are often mentioned as requiring careful management, but the specific risks vary from person to person and must be adjusted under the guidance of a doctor: 1. The combined use of alcohol and central nervous system depressants (such as benzodiazepines, sedatives, hypnotics or some anti-epileptic drugs) • Alcohol itself can reduce inhibition and increase impulsivity. If used in combination with other drugs with similar sedative, cognitive or emotional suppression effects, it may cause emotional loss of control or increase behavioral impulsivity, thereby potentially increasing the risk of self-harm. 2. Combination of antidepressants (especially selective serotonin reuptake inhibitors [SSRIs]) with other drugs that affect the serotonin system (such as monoamine oxidase inhibitors [MAOIs], certain analgesics, some migraine drugs, or herbal preparations such as St. John's wort) • This combination not only has the risk of serotonin syndrome, but some studies have also found that some young patients may be accompanied by mood swings and suicidal ideation in the early stages of antidepressant treatment, so it is necessary to be vigilant about possible mood instability and impulsiveness when using them together. 3. Multiple psychotropic drugs (for example, the simultaneous use of multiple mood-regulating drugs, such as antidepressants, antipsychotics, and mood stabilizers) • Combination medication is often required for the treatment of complex or severe mood disorders, but multiple mechanisms of action and mutual pharmacological effects may make some patients more vulnerable to mood regulation and increase the risk of self-harm or impulsive behavior. This requires doctors to closely monitor changes in the early stages of treatment and when adjusting drug doses. 4. Certain stimulant drugs are used in combination with other drugs that affect mood or psychological state • Some stimulants or drugs with large fluctuations in efficacy may cause mood swings or impulsive behavior changes when used in combination, and theoretically may also increase the risk of self-harm, but there are large individual differences in this regard, which requires case evaluation. It is important to emphasize that: • Each person may react differently to drugs, and the potential side effects of existing drugs may also be related to the patient's own mental illness, previous drug history, genetic factors and living environment. • When formulating a drug treatment plan, the doctor will carefully assess the relevant risks and reduce the risk of adverse events by adjusting the dosage, monitoring adverse reactions and regular follow-up visits. • If you or your relatives and friends experience severe mood swings, impulsive behavior or self-harm tendencies when using any drug, you should communicate with the medical provider in a timely manner and adjust the treatment plan if necessary. In short, please be sure to consult your attending physician or mental health expert for specific circumstances regarding the combined use of drugs and the risk of self-harm. They will make the most appropriate judgment and treatment based on your specific situation.