The following content is for general scientific reference only and is not a substitute for professional medical or mental health advice. If you or someone close to you is facing a substance abuse problem, please be sure to seek professional help as soon as possible (such as a doctor, drug rehabilitation institution, psychologist, etc.). The use of different types of drugs together is usually called "polydrug use" or "drug mixing". Its effects and risks are very complex and unpredictable due to factors such as the specific types of drugs used, dosages, individual differences, and the use environment. The following are some common potential effects and risks: 1. Cross-enhancement and side effect superposition • Some drugs may have a slight inhibitory or stimulatory effect on a certain system of the body when used alone, but when they are used in combination, they may enhance each other. For example, the simultaneous use of central nervous system stimulants (such as methamphetamine) and depressants (such as opium drugs) may cause dramatic fluctuations in physiological indicators such as heart rate, blood pressure, and respiration. • The dosage is difficult to control and the interaction between drugs may increase the risk of poisoning and overdose. 2. Unpredictable drug interactions • Each drug has different metabolism and mechanism of action in the body. When mixed, the enzyme system in the body may be disturbed, resulting in partial drug retention or degradation changes, making the actual blood drug concentration unpredictable. • This uncertainty may lead to unexpected serious side effects, such as arrhythmia, respiratory depression, brain damage, and even fatal risks. 3. Psychological and behavioral risks • Different types of drugs may affect emotions, cognition and judgment at the same time, leading to a confused mental state, hallucinations, delusions, panic or acute mental symptoms. • In this state, users are more likely to make dangerous decisions, increasing the risk of accidents and violent behavior. 4. Long-term health hazards • Long-term mixed use of drugs may accelerate organ damage, such as cardiovascular system, liver, kidney and nervous system. • The risk of mental addiction and dependence will also increase significantly. At the same time, compound drug dependence is often more difficult to quit and treat than single drug dependence. 5. Unpredictable individual differences • Individual physical condition, genetic characteristics, use experience and other factors will affect the reaction after drug mixing. Some people may be particularly sensitive to a certain combination, while others may experience varying degrees of tolerance and side effects. In summary, mixing different types of drugs greatly increases unpredictable and serious health risks, which may lead to acute poisoning, permanent physical and psychological damage, and even death. The safest option is to avoid using illegal drugs completely and seek help and intervention in a timely manner when encountering use or dependence problems. Reminder again: The information in this article is for reference only and does not constitute medical or drug rehabilitation advice. If you or someone you know is facing drug-related problems, please contact a professional medical institution or drug rehabilitation service center as soon as possible.