The use of gene editing technology to design microorganisms that can permanently affect human decision-making and emotions is currently possible in scientific theory, but it faces multiple technical, ethical and practical application challenges. The following is a comprehensive analysis： --- ###**Scientific possibility** 1. **The association between microorganisms and human behavior** Studies have shown that intestinal microorganisms (such as certain probiotics) interact with the central nervous system through the gut-brain axis, which may affect mood (such as anxiety, depression) and cognitive function. For example： -Some strains can produce neurotransmitters (such as serotonin, gamma-aminobutyric acid/GABA)； -Microbial metabolites may regulate the immune system or vagus nerve signaling. 2. **The potential of gene editing technology** Through tools such as CRISPR, microorganisms can be designed： -Enhance its ability to produce specific neuroactive substances； -Introduce new genes to synthesize new regulatory molecules； -Optimize its colonization ability in the host intestine to achieve long-term existence. --- ###**Technical challenge** 1. **Accuracy and safety** -It is necessary to ensure that microorganisms only target specific physiological processes to avoid off-target effects or interfere with the normal function of the host； - Microorganisms may evolve or transfer genes horizontally in the host, resulting in unpredictable mutations. 2. **Durability and controllability** -The human intestinal environment is complex, and foreign microorganisms may be cleared by the immune system or fail to compete with native flora.； -“Molecular switches” need to be developed to control microbial activity and prevent excessive proliferation or side effects. 3. **Individual differences** -Host genes, diet, lifestyle and other factors can affect the effect of microbial colonization, resulting in inconsistent results. --- ###**Ethics and Social Risks** 1. **Risk of abuse and manipulation** -Such technologies may be used for non-therapeutic purposes (such as enhancing specific behaviors, military uses), causing ethical disputes； -Uncertainty about long-term effects may threaten personal autonomy and mental health. 2. **Regulation and Privacy** -The current global regulatory framework for gene-edited microorganisms is not perfect, especially when it comes to human behavioral intervention.； - Microorganisms may have uncontrollable ecological effects through human-to-human transmission or environmental release. --- ###**Potential application scenarios** 1. **Medical field** -Treatment of mental illnesses (such as depression, anxiety) or neurodegenerative diseases； -Regulate appetite and decision-making behavior in patients with metabolic syndrome. 2. **Research tools** -Used to analyze the mechanism of enterocerebral axis or basic neuroscience research. --- ###**Conclusion** **Theoretically feasible, but the practical application is far away. ** In the short term, gene-edited microorganisms are more likely to be used to treat specific physiological diseases (such as inflammatory bowel disease).