In scientific research and technological innovation, ethical review is not an "obstacle”, but a necessary mechanism to ensure the bottom line of human civilization. The following is a framework for in-depth thinking on this issue： **1. The lesson of history: the Price of breaking Ethics** -**Tuskegee Syphilis Experiment** (1932-1972): 600 black syphilis patients were deliberately not treated in the name of ”research", resulting in lifelong victimization of participants and their families. Such cases prove that “innovation” that lacks ethical constraints may lead to systematic evil. - **Gene editing baby incident**(2018): He Jiankui's team bypassed ethical review to carry out gene editing of human embryos, which led to condemnation by the global scientific community, imprisonment of the scientists involved, and collective stigmatization of research in the field of gene therapy. **2. The essential value of ethical review** -**Risk prediction mechanism**: The review committee includes experts in many fields such as law, sociology, and philosophy, and can identify long-term social impacts that researchers may ignore. For example, brain-computer interface experiments may raise new human rights issues such as cognitive rights and privacy rights. -**The cornerstone of trust**: According to a 2022 Nature survey, 73% of the public's trust in scientific research is directly related to the transparency of ethical review. Bypassing censorship is equivalent to overdrawing society's trust capital in science. **3. The dynamic game of Innovation and Ethics** -**Compliance innovation path**: The rapid development of mRNA vaccines has proved that breakthrough technologies can be promoted within the ethical framework. The key lies in establishing a “pre-review communication mechanism” with review agencies in the early stage. For example, CRISPR technology has gradually broken through hierarchical review (in vitro cells→ animal models→humans). - **Ethical paradigm revolution**: When the existing norms are obviously lagging behind, the iteration of standards should be promoted through academic community debate. For example, a new ethical review matrix is being established in the field of artificial intelligence, covering dimensions such as algorithmic bias and environmental costs, rather than directly bypassing rules. **4. The Butterfly Effect of Personal Decision-making** -Short-term personal gains (such as the early publication of papers) may cause a subject-level crisis: due to controversial research such as the Milgram electric shock experiment in the psychology community, all social psychology experiments after 2010 must provide ethical pre-registration. -The globalization of academic misconduct databases (such as Retraction Watch) makes any violation records affect international cooperation opportunities for life. **Conclusion: True innovators reshape the rules, not break the rules** The following action paths are recommended： -**Construct an ethical feasibility plan**: Transform “controversial” into academic discussion in the review and defense, such as designing phased experiments to prove that the risks are controllable. -**Participate in standard-setting**: Join ethical consensus organizations in your field (such as the IEEE Global Ethics Initiative) to promote innovation at the level of rule improvement -**Social mirror image of predictive technology**: Use ”reverse thinking" to evaluate scenarios where research may be abused, and take the initiative to set up ethical firewalls The great breakthroughs in the history of science, from organ transplantation to the moon landing program, have all been achieved within the ethical framework. The courage to pursue the truth is precisely reflected in the awe of the bottom line of human nature.