In response to society's preference for skin color, there are indeed some means of changing skin color in the fields of medicine and beauty, but its “permanent”, safety and ethical issues need to be carefully evaluated. The following are relevant methods and considerations： --- ###**1. Medical/Aesthetic methods** 1. **Laser treatment** -**Principle**: Melanin is broken down by a laser of a specific wavelength to reduce pigmentation (such as freckles and sunburn). -**Effect**: Multiple treatments are required, and the effect can last for several years, but the production of new pigments cannot be completely prevented (such as continued sun exposure). -**Limitations**: Limited changes in natural skin tone, mainly used for local pigment problems, not systemic changes. 2. **Chemical peels (deep peels)** -**Principle**: Use high-concentration acids (such as TCA) to exfoliate the epidermis and promote new skin regeneration. -**Effect**: It may temporarily brighten the complexion, but it may rebound if it is affected by ultraviolet rays, hormones and other factors for a long time. 3. **Whitening injections (such as glutathione)** -**Principle**: Inhibit melanin synthesis through antioxidants. -**Controversy**: The effect lacks long-term data support, and may cause side effects such as liver and kidney damage and skin rashes. Many countries (such as the FDA) have not approved it for whitening. 4. **Skin transplantation/epidermal cell transplantation** -**Principle**: Surgical transplantation of lighter-skinned skin to other areas. -**Risk**: The trauma is large, the risk of scarring is high, the skin tone may be uneven, and it is rarely used for non-medical needs (such as burn repair). 5. **Experimental technologies (such as gene editing)** -**Status quo**: In theory, skin tone can be changed by regulating melanin synthesis genes (such as MC1R), but there is no clinical application and there are ethical and safety disputes. --- ###**2. Key considerations** 1. **Safety and risk** -Most methods (such as lasers and peels) require repeated maintenance and may be accompanied by infections, scars, or abnormal pigmentation. -Invasive surgery (such as transplantation) has a very low risk-benefit ratio and is not recommended for non-essential cosmetic purposes. 2. **Ethics and social impact** -**Colorism and race issues**: Catering to skin color preferences may strengthen social inequality, and we need to be wary of suppressing diverse aesthetics. -**Medical ethics**: Doctors should evaluate the psychological motivation of patients and give priority to guiding the concept of health, rather than unconditionally meeting their needs. 3. **Regulatory restrictions** -Some countries strictly regulate whitening products (such as intravenous glutathione injection is prohibited) and must comply with local laws. --- ###**3. Alternative suggestions** -**Psychological support**: If appearance anxiety occurs due to social pressure, psychological counseling or self-identity building is more important. -**Non-permanent option**: Use safe whitening skin care products or beauty black products (such as DHA beauty black agent) to temporarily adjust the skin tone. -**Advocate a diverse aesthetic**: Promote society to accept the diversity of skin colors and reduce unnecessary physical transformation. --- ###**Conclusion** There is currently no completely safe and permanent medical method to completely change the natural skin tone. The prior art is mostly aimed at local pigment problems and requires long-term maintenance. Any decision should weigh health risks, ethics and social implications, and prioritize psychological and skin health rather than blindly catering to external standards.