Regarding the optimal use of drug doses, the following points need to be clarified： 1. **Individual differences** The optimal dose of the drug is affected by a variety of factors, including the patient's age, weight, health status, liver and kidney function, genetic differences, and other drugs being used. For example, children and the elderly usually need to adjust the dose, while patients with liver and kidney insufficiency may need to reduce the dose to avoid toxicity. 2. **Drug type and indications** The treatment window (range of effective dose and intoxication dose) of different drugs varies greatly. For example： -**Paracetamol (acetaminophen)**: The maximum daily dose for adults usually does not exceed 4000mg. Overdose may cause liver damage. -**Chemotherapy drugs**: The dose needs to be calculated based on the surface area of the body and adjusted under strict monitoring. -**Antibiotics**: The dose needs to be determined according to the type of infection and pathogen sensitivity. If it is too low, it may lead to drug resistance. 3. **Balance of efficacy and safety** The maximum effect is not equal to the maximum dose. Many drugs have a "ceiling effect”, where the efficacy no longer improves after a certain dose is exceeded, but the risk of side effects is significantly increased (such as the risk of respiratory depression from opiate painkillers). 4. **Evidence-based** The recommended dose of a drug is usually based on clinical trials and drug instructions, but individual adjustments are required in practical applications. For example, the dose of warfarin needs to be adjusted according to regular blood clotting tests (INR value). 5. **Important advice** -**Consult a professional medical staff**: The doctor or pharmacist will make a plan based on your specific situation (such as blood test report, medical history). -**Do not adjust the dose by yourself**: Especially prescription drugs, random increase or decrease may lead to treatment failure or serious adverse reactions. -**Refer to authoritative resources**: such as drug brochures, UpToDate, or guidelines issued by the State Drug Administration. **Example scenario**： If you ask “the optimal dose of Ibuprofen”, the conventional recommendation may be 200-400 mg per time for adults, once every 6-8 hours, and no more than 1200-3200 mg per day (depending on the indication). However, this dose may not be applicable to patients with arthritis, pregnant women, or patients with cardiovascular disease. **Conclusion**: In order to ensure safety and effectiveness, please be sure to use the drug under the guidance of a doctor or pharmacist.