The following information is for general scientific reference only and does not constitute medical advice. If you or someone you know is troubled by drug use problems, please seek professional medical or psychological help in time. 1. Many painkillers, especially those containing opioid ingredients (also called "opioids" or "opioids"), such as morphine, oxycodone, hydrocodone, fentanyl, etc., may be abused for pleasure because their mechanism of action is related to the reward system in the brain. 2. Working principle: This type of drug mainly works by activating μ-opioid receptors in the brain and spinal cord. When opioids bind to these receptors, they not only relieve pain, but also prompt the brain to release dopamine, an important neurotransmitter related to pleasure and reward, so abuse may produce short-term euphoria (pleasure). 3. Risk of abuse: • Addiction: Repeated abuse will cause the brain to gradually adapt to the peak pleasure produced by the drug and form tolerance, that is, a larger dose is required to achieve the same effect, thus leading to drug dependence. • Health hazards: Overdose of opioids can inhibit the function of the central nervous system, especially the respiratory system, and may cause severe respiratory depression or even fatal respiratory failure. • Other concurrent risks: Long-term abuse may lead to cognitive, behavioral and emotional problems, and may also cause social and psychological distress. 4. Medical management and prevention and control measures: • Normal medication: In a medical setting, doctors will formulate medication plans based on the patient's specific situation, pain level, risk factors, etc. to balance the analgesic effect and side effects. • Strict supervision: Many countries and regions have strict regulations on the prescription, distribution and use of opioids to prevent drug abuse and illegal circulation. • Alternative treatment: In order to reduce the risk of opioid abuse, some medical institutions are promoting non-opioid analgesic measures and multimodal pain management (such as physical therapy, psychological intervention or other drug therapy). 5. Warnings and suggestions on abuse: If such drugs are needed for pain management, it is critical to use them strictly according to doctor's orders; self-adjustment of dosage or method of administration, hoarding of drugs, or sharing of drugs with others may increase addiction and other health risks. For those who have already shown signs of abuse, it is recommended to seek comprehensive treatment and support as soon as possible. Many countries and regions have drug rehabilitation institutions and psychological counseling services. In short, although some analgesics (mainly opioids) are indeed effective in relieving pain, their potential abuse risks and addiction problems cannot be ignored. Correctly understanding the effects and risks of drugs and strictly using them according to professional guidance is crucial to personal health.