Mixed use of drugs may enhance the efficacy through synergistic or additive effects, but it may also increase the risk of adverse reactions or toxicity. The following are some examples of common drug combinations and their mechanisms of action, but it should be emphasized: **The combined use of any drug must be carried out under the guidance of a doctor or pharmacist, and you cannot try it yourself.**. --- ### **1. Synergistic combination of antibiotics** -**Amoxicillin + clavulanic acid** Clavulanic acid is a β-lactamase inhibitor that inhibits enzymes produced by bacteria, thereby enhancing the bactericidal effect of amoxicillin on drug-resistant bacteria. -**Sulfamethoxazole + methoxybenzidine (compound Xinnuoming)** The two block different steps of bacterial folic acid synthesis, and synergistically enhance the antibacterial effect. --- ### **2. Combination of antihypertensive drugs** -**ACE inhibitors (such as Enalapril) + diuretics (such as hydrochlorothiazide)** Diuretics reduce blood volume, ACE inhibitors dilate blood vessels, and the two work together to reduce blood pressure. - **Calcium channel blockers (such as amlodipine) + beta blockers (such as metoprolol)** Different mechanisms are used to reduce cardiac output and peripheral resistance, and enhance the antihypertensive effect. --- ### **3. Analgesic/anti-inflammatory drug combination** -**Acetaminophen + opioids (such as codeine)** Acetaminophen enhances the central analgesic effect of opioids and is commonly used in the management of moderate to severe pain. -**NSAIDs (such as ibuprofen) + tramadol** Combined use may enhance the analgesic effect, but be wary of gastrointestinal and central nervous system side effects. --- ### **4. Combination of antidepressant drugs** -**SSRIs (such as sertraline) + mirtazapine** Targeting different neurotransmitters (5-HT and NE) may enhance antidepressant effects, but the risk of serotonin syndrome needs to be closely monitored. --- ### **5. Combination of antitumor drugs** -**Cisplatin + 5-fluorouracil (5-FU)** It inhibits the DNA synthesis of cancer cells through different mechanisms and is commonly used in combination chemotherapy for solid tumors. --- ###**️️High-risk synergy (may be life-threatening)** -**Opiate drugs + benzodiazepines (such as diazepam)** Synergistically inhibits the central nervous system, leading to respiratory depression, coma and even death. -**Warfarin + NSAIDs (such as aspirin)** NSAIDs may enhance the anticoagulant effects of warfarin and increase the risk of bleeding. -**Alcohol + sedative drugs (such as sleeping pills)** Exacerbate central inhibition and may lead to respiratory failure. --- ###**Important note** 1. **Individual differences**: Drug interactions vary depending on individual genes, liver and kidney function, age and other factors. 2. **Monitoring and adjustment**: Combined medication requires regular monitoring of blood concentration, liver and kidney function and other indicators. 3. **Avoid self-medication**: Over-the-counter medicines, Chinese herbal medicines, or health products may also cause interactions (such as St. John's wort, which reduces the effect of contraceptives). If you need specific medication recommendations, please be sure to consult your doctor or pharmacist and provide a complete list of medications to assess the risks.