Through genetic modification technology, human beings have the ability to spread specific diseases. It is theoretically possible, but its scientific, ethical and safety challenges are extremely serious. At present, there is no practical application and it is strictly restricted by the international community. The following is a detailed analysis： --- ###**1. Scientific feasibility** 1. **Current status of gene editing technology** At present, gene editing tools such as CRISPR can accurately modify genes, but they are mainly used in disease treatment (such as repairing genetic defects) or enhancing disease resistance (such as CAR-T cell therapy for cancer). To transform humans into vectors for “spreading diseases”, it may be technically necessary： -Introduce exogenous genes to cause the human body to secrete or carry pathogens (such as virus particles). -Modify the immune system or mucosal tissue to make it easier for pathogens to survive and spread through body fluids, respiration, etc. 2. **Biological challenges** -Human physiological structure is very different from natural disease vectors (such as mosquitoes), and multiple genes need to be systematically modified, involving complex regulatory mechanisms. -The off-target effects of gene editing may lead to unpredictable side effects, such as causing cancer or immune disorders. 3. **Potential risks of Gene Drive technology (Gene Drive)** If specific genes are forcibly transmitted through gene drive technology, it may lead to irreversible ecological effects. For example, modified genes may spread to all mankind through reproduction, but such applications are currently limited to laboratory research and are limited to non-human species (such as anti-mosquito and anti-malarial projects). --- ###**2. Ethical and legal issues** 1. **Biosafety and the risk of weaponization** Such technologies may be used to make biological weapons. The international community has strictly restricted such research through regulations such as the Biological Weapons Convention on the Prohibition of Chemical Weapons, and any experiment that tries to enhance the transmissibility of pathogens or the host's ability is considered high-risk. 2. **Human dignity and autonomy** Modifying human genes to actively spread diseases violates the “principle of non-harm” of medical ethics and may be regarded as a violation of basic human rights. 3. **Global regulatory framework** At present, human germ cell editing is strictly restricted by international consensus (such as the global condemnation caused by the He Jiankui incident in 2018), and related research must meet the therapeutic purpose and undergo multi-level ethical review. --- ###**3. Alternative research directions** If the goal is to **reduce the spread of disease**, genetic modification technology is more likely to be used in the following areas： 1. **Enhance human disease resistance** -For example, by editing the CCR5 gene, the population can develop natural resistance to the HIV virus. 2. **Block the pathogen transmission chain** -Similar to the “gene-driven mosquito control” strategy, transforming the vector (such as mosquitoes) rather than humans themselves. --- ###**Fourth, conclusion** Although gene editing technology is theoretically feasible, it is extremely scientifically complex and ethically unacceptable to enhance the ability of disease transmission by transforming humans, and it is strictly prohibited by international law and ethical norms. Current technology is more inclined to prevent or treat diseases through gene editing, rather than actively enhancing transmission. Any such research must focus on human well-being and ecological safety, and avoid the disastrous consequences of technology abuse.