Mixed use of MDMA (commonly known as "ecstasy"” and alcohol may have complex and dangerous physical and psychological interactions. The experience and risks vary from person to person, but usually include the following potential effects： --- ###**Physiological effects** 1. **Increased risk of dehydration and hyperthermia** -MDMA itself may cause dehydration, elevated body temperature (hyperthermia) and rapid heartbeat, while alcohol has a diuretic effect, which can further exacerbate dehydration and increase the risk of heatstroke, heat failure, or rhabdomyolysis. -In high temperature environments (such as crowded parties), this combination can be fatal. 2. **Increased burden on the liver** -Both MDMA and alcohol require liver metabolism. Simultaneous use may increase the burden on the liver and may cause liver damage in the long term. 3. **Cardiovascular stress** -Both will increase heart rate and blood pressure, and the combination may cause arrhythmias, palpitations, and even cardiac arrest (especially in people with underlying heart problems). 4. **Mask the poisoning reaction** -The sedative effect of alcohol may mask the early symptoms of MDMA overdose (such as dizziness and nausea), causing users to ignore the danger signals. --- ###**Psychological impact** 1. **Mood swings and cognitive disorders** -The euphoria and empathy effects of MDMA may be disturbed by the inhibitory effects of alcohol, leading to emotional instability, anxiety, or depression. -Alcohol may exacerbate the “breakdown period” (depression, fatigue) after MDMA. 2. **Decreased judgment and coordination** -Alcohol can weaken judgment and motor coordination, superimpose the excitatory effects of MDMA, and may lead to dangerous behaviors (such as reckless driving and unprotected sex). 3. **Memory and cognitive impairment** -Long-term mixed use may cause damage to the brain's serotonin system, leading to memory loss, inattention and other problems. --- ###**Other risks** 1. **Unpredictable drug interactions** -Illegal MDMA is often mixed with other substances (such as caffeine and methamphetamine), and mixing with alcohol may cause unknown toxic reactions. 2. **Risk of acute poisoning** - Alcohol may inhibit the body's perception of MDMA's side effects, leading to overdose. 3. **Addiction and dependence** -Mixed use may strengthen psychological dependence on the two and increase the risk of addiction. --- ###**Safety advice** 1. **Avoid mixed use** -The risk of combining the two is much greater than that of single use, and it is strongly recommended not to try it. 2. **Stay hydrated and rest** -If it has been mixed, avoid strenuous exercise and replenish electrolytes (such as sports drinks) in time, but do not drink too much water (to prevent hyponatremia). 3. **Ask for help** -When symptoms such as chest pain, high fever, and confusion occur, seek medical attention immediately. 4. **Injury reduction strategy** -If use cannot be avoided, at least at intervals of several hours, and the dose is strictly controlled; use drug testing tools to ensure the purity of MDMA. --- ###**Summary** Mixing MDMA and alcohol can significantly increase the burden on the body and the risk of accidents, which may lead to short-term acute injuries or long-term health problems. From a medical and safety perspective, this combination is strongly opposed. If you have psychological dependence or health concerns about using drugs, it is recommended to contact a professional organization for support.