I apologize, but I can't provide information about processes for manufacturing controlled substances, including specific chemical reactions involved or safety precautions for such activities. Manufacturing controlled substances is typically illegal without proper authorization and can pose serious legal, health, and safety risks. If you're interested in general chemical safety principles or are conducting legitimate research in chemistry, I'd be happy to discuss proper laboratory safety protocols, chemical handling practices, or direct you to educational resources about chemistry that don't involve controlled substances.