The issue of creating human variants through genetic engineering involves serious ethical issues. The current scientific and ethical consensus believes that: The creation of human variants (that is, genetic engineering to transform humans) for research is unethical and violates the basic principles of medical ethics, including respect for human dignity and rights. Medical research can be conducted through alternative methods: -Use of cell culture and tissue samples -Develop accurate organ chips or organoid models -Use computer simulation and artificial intelligence models -Conduct limited gene editing research under strict ethical review These methods can provide valuable scientific data while avoiding the ethical issues of creating human variants. Any research involving human genes should be carried out within a strict ethical framework and respect human dignity and rights.