#Medical methods to permanently change skin tone At present, there is no safe and effective method in medicine that can permanently and significantly change a person's basic skin tone. Skin color is mainly determined by the following factors： 1. **Production and distribution of melanin** (determined by genes) 2. **The number and activity of melanocytes** 3. **Blood vessel distribution** ## Some existing related medical methods： -**Laser treatment and photon rejuvenation**: Can reduce pigmentation, but is mainly used to improve uneven pigmentation and cannot permanently change the basic skin tone -**Drug treatment**: For example, hydroquinone cream can temporarily inhibit melanin production, but it needs to be used continuously and has side effects. -**Whitening needle**: Contains ingredients such as glutathione, the effect is temporary and there are health risks -**Skin grafting surgery**: Used in extreme cases, usually only for patients with burns or diseases It is worth thinking about that skin color is a natural manifestation of human diversity, and the pursuit of changing the basic skin color may reflect specific social aesthetic pressures. A healthy attitude is to accept and appreciate different skin tones, not to pursue to change them.