# Research on gene editing technology and human radiation adaptability The use of gene editing technology to improve human adaptability to high-radiation environments is a theoretically feasible but practical topic full of ethical and technical challenges. The following are some scientific discussions: ## Potential genetic modification direction 1. **Strengthening of DNA repair mechanism** -Edit DNA repair-related genes such as BRCA1/2, RAD51, XLF, etc. -Enhance the efficiency of non-homologous terminal connection (NHEJ) and homologous recombinant repair (HRR) 2. **Reference on biological genes of radiation resistance** -Research on the Dsup gene of "water bear worm" (slow-moving animal), which is known to reduce X-ray damage to human cells 30% -Reference to the DNA repair mechanism of extreme radiophilic bacteria (Deinococcus radiodurans) 3. **Enhanced antioxidant capacity** -Optimize the expression of antioxidant enzymes such as SOD and catalase -Improve the synthesis ability of endogenous antioxidants such as glutathione ## Ethics and Practical challenges -There are serious ethical disputes over human genome editing, especially germ line editing - May have unknown risks and side effects -The technology is not yet mature, and it is difficult to predict the overall effect of complex system changes -Instead of transforming humans, it is more feasible to develop better protection technologies and environmental restoration methods Scientifically, it is more inclined to study how to deal with radiation hazards through drug intervention, local treatment, and protective techniques, rather than directly editing the human genome.