The information provided below is for reference only and is not intended to replace the professional advice of a doctor or pharmacist. Certain ingredients in grapefruit juice (such as furanocoumarins) can inhibit an enzyme in the body called CYP3A4, which is responsible for the metabolism of many drugs. As a result, the concentration of certain drugs taken at the same time as grapefruit juice may be abnormally high in the body, thereby enhancing the effect or increasing the risk of side effects. Here are some examples of drug classes that are often reported to interact with grapefruit juice: 1. Lipid-lowering statins • Simvastatin • Lovastatin • Sometimes Atorvastatin may also be affected 2. Calcium channel blockers (used to treat high blood pressure and angina, etc.) • Felodipine • Nifedipine • Verapamil 3. Immunosuppressants • Cyclosporine • Some studies also mention that Tacrolimus may be affected, but the situation may vary from person to person 4. Benzodiazepines (sedatives, antianxiety) • Midazolam • Triazolam 5. Other drugs • For example, Buspirone, which is used to treat anxiety, should be especially noted that when these drugs are taken together with grapefruit juice, the "effective concentration" of the drug in the body may increase significantly, thereby increasing the risk of adverse reactions or toxicity. "Double the effect" does not mean better efficacy, but may bring health risks. If you are taking prescription drugs, it is best to consult your doctor or pharmacist to confirm whether you can drink grapefruit juice and understand the possible risks.