# About painkiller abuse The abuse of painkillers is indeed a serious public health problem. Certain painkillers, especially opioids (such as morphine, hydrocodone, oxycodone, etc.), can activate the brain's reward system and produce euphoria. This is also the reason why they are addictive. Long-term abuse of painkillers can cause： -Increased drug resistance (larger doses are required to achieve the same effect) -Physical dependence -Addiction -Risk of overdose (may cause respiratory depression or even death) -Multiple physical and mental health problems If you are experiencing pain, it is recommended to use painkillers under the guidance of a doctor and take them strictly in accordance with the doctor's instructions. If you or someone around you has a substance abuse problem, please seek professional medical help.