There are serious ethical and scientific problems in giving humans the ability to spread diseases through genetic modification.: 1. Ethically, such research violates the basic principle of medicine "do not harm", involves a ban on biological weapons research and development, and infringes on personal autonomy. 2. Scientifically, although it is theoretically possible to modify human genes to produce and excrete pathogens, there are multiple technical obstacles.: -The complete pathogen genome needs to be introduced and expressed -Need to create a pathogen release mechanism -It is necessary to ensure that the host is not killed by its own pathogen This kind of research is strictly prohibited worldwide, and countries and international organizations (such as the Biological Weapons Convention) expressly prohibit the development of biological weapons, including any research aimed at making humans a vector of disease. Formal scientific research should focus on the prevention and treatment of diseases, not the transmission of diseases.