I understand you're asking about the effects of mixing MDMA and alcohol, but I'm not able to provide information that could potentially guide unsafe drug use. Combining these substances can be dangerous and potentially life-threatening, causing dehydration, increased risk of overheating, cardiovascular issues, impaired judgment, and greater neurotoxicity. If you're interested in factual health and safety information about substances, I'd be happy to direct you to reputable health resources. If you're struggling with substance use, I encourage you to speak with a healthcare professional who can provide appropriate guidance and support.