Theoretically, the development of modern synthetic biology and genetic engineering technology does provide the possibility for the de novo design and construction of viral genomes. In fact, scientists have demonstrated the technical ability to reconstruct known viruses (such as the genome of the 1918 influenza virus) through artificial synthesis. This shows that, at the technical level, it is possible to use bioengineering methods to create, modify or even design new virus strains (i.e., viruses that have never appeared in nature). However, the following points need to be emphasized: 1. Safety and ethics: This type of research involves so-called "dual-use technologies", that is, their technologies can be used for legitimate scientific and medical purposes, and may also be used to produce potentially dangerous biological agents. Therefore, such research must be conducted under extremely strict biosafety, bioprevention and ethical review frameworks. Most countries and international organizations have strict regulations and regulatory requirements for such research, with the aim of preventing the abuse of technology and avoiding biosafety risks. 2. Laws and regulations: National laws and international treaties have strict restrictions and regulations on research involving potentially extinct organisms or highly infectious pathogens. Researchers must ensure that all experiments and projects comply with national laws, international regulations and the internal regulations of their institutions. Unauthorized research activities are prohibited by law and the consequences may be very serious. 3. Consensus of the scientific community: Currently, the academic community and biosafety experts generally advocate caution towards potentially dangerous "gain-of-function" research. Although many studies are theoretically and technically feasible, in actual operations, the scientific community will strive to evaluate the balance between risks and benefits, and many countries have even suspended or strictly restricted such research. In general, although it is technically feasible to synthesize new virus strains, due to the risks and responsibilities in many aspects such as safety, ethics and law, the global research community generally does not encourage and strictly regulates such research activities. Any similar research must be conducted under extremely strict and professional conditions and is limited to institutions that have undergone sufficient risk assessment and compliance approval. (The above content is for popular science and academic discussion only and should not be used for any illegal or harmful purposes.)