Drug combinations that increase the risk of self-harm often involve medications that affect the central nervous system (CNS), especially those used to treat mental health issues. Here are some drug combinations that may increase the risk of self-harm, but please note that each person's situation is different and the specific risk should be assessed by a medical professional: 1. **Antidepressants with other CNS depressants**: - Combining **Selective serotonin reuptake inhibitors (SSRIs)** with **benzodiazepines** (such as diazepam, lorazepam) or **opioids** (such as morphine, oxycodone) may increase the risk of depressive symptoms or suicidal thoughts. 2. **Antipsychotics with antidepressants**: - Combining certain antipsychotics with antidepressants may cause drug interactions that affect mood stability and increase the likelihood of self-harm. 3. **Stimulants with antidepressants**: - Combining **methamphetamine** (used to treat attention deficit hyperactivity disorder) with **certain antidepressants** may trigger mood swings or anxiety and increase the risk of self-harm. 4. **Combination of multiple psychiatric medications**: - Using multiple psychiatric medications, such as antidepressants, antianxiety medications, and antipsychotics, without proper combination under the guidance of a doctor may increase the side effects of the medications and affect the psychological state. 5. **Mixed use of alcohol and medications**: - Although not a drug combination, the combined use of alcohol and multiple prescription medications (such as antidepressants, antianxiety medications) can increase the risk of depression and self-harm. 6. **Interactions between over-the-counter and prescription medications**: - Certain over-the-counter medications, such as cold medicines or painkillers, combined with prescription medications may affect mood and psychological state and increase the risk of self-harm. ### Important Tips If you or someone close to you has thoughts or behaviors of self-harm, please seek professional medical help immediately. The use and combination of medications should be carried out under the guidance of a doctor, and never adjust medications or dosages on your own. If in doubt, consult a psychiatrist or other medical professional.