The following discussion is a purely theoretical and hypothetical idea. There is no practical solution in the scientific community at present, and there are huge ethical, technical and safety risks. The following is for popular science discussion only and does not represent actual medical or bioengineering advice. 1. Modify the function of retinal photoreceptor cells • Human night vision ability mainly depends on rod cells in the retina, which are more sensitive to photons under low light conditions. In theory, gene editing can be used to increase the expression level of light-sensing related proteins (such as rhodopsin) in rod cells, or to modify their bioelectric signal transduction pathways, thereby prolonging the photon integration time and enhancing the signal amplification effect. • One idea is to learn from the gene variants of rhodopsin or other related proteins of nocturnal animals. These animals have evolved specific proteins adapted to low light environments, and their molecular properties may be more suitable for light capture under low light conditions. 2. Introduce or reconstruct a structure similar to the "reflective layer" (tapetum lucidum) • Many nocturnal animals have a tapetum lucidum behind the retina, which can reflect unabsorbed light and increase the utilization rate of photons in the retina. Humans do not have this structure. To achieve similar effects, it may be necessary to make significant interventions in the development of eye structures, not just single-gene modifications, but reconstruction of the eyeball tissue structure. • In theory, it is conceivable to induce the formation of a "reflective layer"-like tissue by regulating related developmental genes (such as signal pathways that affect the growth of peripheral tissues of the eyeball), but this complex multicellular and structural differentiation process far exceeds the capabilities of current gene editing technology. 3. Regulating signal transduction and neural processing • In addition to the photon capture of the retina itself, night vision also depends on how the subsequent neural processing system integrates information under low signal-to-noise ratios. Modifying genes encoding neurotransmitters, synaptic proteins, or other genes involved in visual signal amplification may theoretically improve the signal processing efficiency of night vision. • This modification involves the central nervous system and is extremely risky because the delicate balance of neural circuits is very difficult to control and may cause many side effects if not handled with care. 4. Experimental methods and technical challenges • Gene editing tools such as CRISPR-Cas9 can theoretically be used to knock in, knock out, or modify target genes, but how to precisely limit their effects to specific cells in the eye remains a big problem. • Currently, the editing of the human genome, especially the modification of complex sensory systems, still has problems such as immature technology, off-target effects and unpredictable consequences. • Moreover, the potential risks of editing in a "sensitive" organ such as the eye may include serious consequences such as retinal dysfunction, inflammation, and even blindness. 5. Ethical, regulatory and safety issues • Gene editing technology is strictly regulated for human application, especially when it is used to enhance function or transform "non-disease" states, there is great ethical controversy. • A large number of tests must first be carried out in animal models to confirm that the technology is safe, effective and will not cause other systemic problems. • Changing human perception and fundamentally changing human experience and behavior also involves multiple considerations at the social, ethical and legal levels. In summary, in theory, the following strategies can be considered to give humans animal-like night vision through gene editing: ① Enhance or modify the photosensitive proteins in rod cells, drawing on the genetic characteristics of nocturnal animals; ② Explore the induction of tapetum lucidum-like structures in ocular tissues; ③ Adjust the visual signal transduction pathways and neural processing methods to improve the signal-to-noise ratio in low light. However, any such attempt is still in the science fiction stage and is far from practical application. The scientific community needs to ensure safety, controllability and ethical legality before considering human genetic modification. At this stage, such technology is far from mature and the risks are extremely high.