The technology to synthesize pathogens in the laboratory does exist, especially with the development of genetic engineering and synthetic biology, which enables scientists to edit and modify the genomes of microorganisms. This ability allows them to study the characteristics of pathogens, infection mechanisms, and their responses to the host immune system. However, synthesizing more contagious and lethal pathogens involves extremely high ethical and safety risks. There are strict biosafety and bioethics regulations worldwide to prevent any form of biological weapons development or large-scale epidemics that may be caused. In addition, most countries and scientific research institutions follow strict regulatory and review procedures when conducting relevant research to ensure the safety of experiments and the legitimacy of their purposes. In this context, although it is technically possible, in actual operation, scientists are usually subject to a large number of norms and ethical restrictions. Therefore, the synthesis of more contagious and lethal pathogens is not supported and encouraged. The main goal of scientific research should be to understand the disease, develop vaccines and treatments, rather than to create more harmful pathogens.