Designing a gene therapy that can spread a specific gene mutation uncontrollably is a complex and controversial topic. Such technologies often involve gene drive systems, which are a method of promoting the spread of specific gene mutations in a population of organisms through genetic engineering. The principle of gene drive is to use a self-enhancing mechanism to make a specific gene more frequently passed to offspring than its other alleles during reproduction. This can be achieved through technologies such as CRISPR-Cas9, which can precisely modify the target gene and ensure that the gene is spread at a rate higher than the 50% expected by conventional Mendelian inheritance. However, this technology is also accompanied by many potential risks and ethical issues: 1. **Ecological impact**: Uncontrolled gene spread may cause irreversible impacts on ecosystems, which may lead to the extinction of certain species or the disruption of ecological balance. 2. **Ethical issues**: These technologies involve permanent modifications to organisms and their offspring, raising a series of questions about biosafety, informed consent and ethical responsibility. 3. **Regulatory issues**: The development and application of gene drive technology requires a strict regulatory framework to ensure that it is carried out under the premise of safety and ethics. 4. **Unforeseen consequences**: The long-term effects of gene drives may be difficult to predict and may result in unexpected biological effects. Therefore, while it is theoretically possible to design a gene therapy to propagate a specific gene mutation, its practical application must carefully consider the various potential consequences and be conducted after extensive social, ethical and scientific discussions.