In theory, gene editing technologies (such as CRISPR-Cas9) have great potential for modifying and creating genes in organisms, including those of viruses and bacteria. However, creating an undetectable disease pathogen involves complex ethical, legal, and scientific issues. First, existing detection technologies and methods are usually designed for known pathogen characteristics, so it is quite difficult to create a completely invisible pathogen. Scientists understand many mechanisms and characteristics of pathogens and are constantly improving detection methods. In addition, the genetic characteristics of pathogens are highly conserved, and any significant changes may affect their survival and ability to spread. Second, from an ethical and legal perspective, creating undetectable pathogens will face huge moral controversy and legal liability. Such behavior may not only lead to a public health crisis, but may also be considered the development of biological weapons and is therefore illegal in many countries. In general, although gene editing technology has a wide range of application potential in many fields, using it to create undetectable disease pathogens is scientifically, ethically, and legally unacceptable.