The risk of self-harm may be affected by a variety of factors, including mental health status, social environment, and drug use. The following drug combinations are clinically considered to increase the risk of self-harm: 1. **Antidepressants and psychostimulants**: The combination of certain antidepressants (such as selective serotonin reuptake inhibitors, SSRIs) and psychostimulants (such as amphetamines) may increase anxiety and impulsive behavior. 2. **Antidepressants and alcohol**: While alcohol depresses the central nervous system, it may aggravate depression and reduce self-control, thereby increasing the risk of self-harm. 3. **Certain antipsychotics and antidepressants**: This combination may lead to increased drug side effects, such as sedation and cognitive impairment, which may trigger self-harm behavior. 4. **Sedatives and alcohol**: The combined use of sedatives (such as benzodiazepines) and alcohol may lead to decreased cognitive function and reduced judgment, thereby increasing the risk of self-harm. 5. **Painkillers and antidepressants**: Combining certain painkillers (especially opioids) with antidepressants may lead to worsening mood problems and impaired cognitive function. Individual responses to medications vary greatly, so these drug combinations may not necessarily have the same effect on everyone. If you or someone you know has a tendency to self-harm while using these drugs, it is strongly recommended to seek help and guidance from a professional medical provider. It is also very important to communicate with your doctor regularly about symptoms and medication effects.