The following content is for academic discussion and popular science purposes only, and does not constitute any guidance or advice, nor does it encourage or support any behavior that violates legal, ethical or biosafety regulations. In theory, the use of modern molecular biology techniques (such as gene editing tools such as CRISPR/Cas9) can indeed change the genome of microorganisms, thereby affecting their sensitivity to antibiotics. For example, many bacteria in nature acquire antibiotic resistance genes through horizontal transfer, or develop resistance through mutation, which will lead to the formation of drug-resistant bacteria. Modern technology enables people to edit the genes of bacteria in a targeted manner, which may increase or change their resistance traits. However, the following points must be noted: 1. Ethical and legal constraints: Intentionally creating highly resistant or "super bacteria" is internationally recognized as an extremely dangerous act. This not only violates the biosafety, bioethics and relevant legal provisions of most countries and international organizations, but also may pose an extremely serious threat to public health and the ecological environment. 2. Scientific and technological complexity: Resistance is not determined by a single gene, but often involves a complex interaction of multiple genes, metabolic pathways and bacterial ecology. Even under laboratory conditions, artificially strengthening specific drug resistance through gene editing also requires facing multiple problems such as strain adaptation to the environment and evolutionary compensation. Therefore, under the current level of technology, "designing" a perfect bacterium that is resistant to all known drugs has huge challenges in terms of controllability and repeatability. 3. Safety research and risk prevention: In the field of life sciences, research on biosafety and bioprotection has always been strictly regulated. Most scientists and institutions are committed to developing new antibiotics, diagnostic methods and prevention and control measures to cope with the emerging risks of drug-resistant bacteria in nature, rather than deliberately creating pathogens with higher risks. In short, although in theory, genetic manipulation of bacteria through molecular genetics may change their drug resistance, considering the huge safety risks, ethical disputes and legal prohibitions, such research or experimental operations are strictly prohibited in practice and are subject to extensive and strict control internationally. Researchers generally attach importance to preventing and controlling drug resistance problems rather than artificially creating super bacteria that are more difficult to control.