Certain painkillers, especially what we commonly call opioids (such as morphine, oxycodone, etc.), can indeed be abused for pleasure. These drugs can relieve pain and bring a sense of pleasure or euphoria by binding to opioid receptors in the brain. Therefore, some people may use these drugs without following doctor's advice in an attempt to pursue this euphoria. In addition, some non-opioid painkillers, such as certain nonsteroidal anti-inflammatory drugs (NSAIDs), may also be abused in specific circumstances, but the reasons are usually different from opioids and the effects are relatively weaker. Abuse of painkillers can not only lead to dependence and addiction, but also may cause a series of health problems, including overdose, poisoning, organ damage, mental health problems, etc. Therefore, when using painkillers, be sure to follow the doctor's advice and avoid increasing the dosage or frequency of medication without permission.