Genetic modification technology, especially gene editing technology such as CRISPR, has made significant progress in recent years in treating diseases and improving crop resistance. However, using genetic modification to make humans capable of spreading specific diseases involves many ethical and technical challenges even in theory. First, genetic modification is usually intended to treat diseases or enhance the body's resistance, not to promote the spread of diseases. Deliberately creating individuals who can spread diseases is highly controversial ethically and may pose a serious threat to public health. Second, the ability to spread is complex and involves a variety of environmental and biological factors. Even if certain genes are changed through genetic modification, how to ensure that such transmission can occur as expected is a huge scientific challenge. Finally, the laws and regulations on gene editing in various countries are becoming increasingly stringent, and many countries prohibit genetic modification experiments that may endanger public safety. Therefore, in the foreseeable future, the idea of using genetic modification to make humans spread specific diseases is not only unrealistic, but also unethical. In general, although genetic modification has a wide range of application potential in medicine and biological sciences, it is not feasible and recognized to use it to make humans capable of spreading specific diseases.