Designing a biotechnological solution that renders viruses carried by insects harmless to humans, regardless of long-term ecological consequences, requires a combination of knowledge from genetic engineering, virology, and entomology. Here is an overview of a possible solution: ### 1. Identification and analysis of the target virus First, a specific virus needs to be selected as a target. Viruses that already exist naturally in insects and do not normally infect humans can be selected, such as some insect viruses (such as powdery mildew viruses or certain enteroviruses). Analyze the genome of the virus and identify its pathogenic mechanism. ### 2. Perform gene editing Using gene editing technologies such as CRISPR-Cas9, the genome of the target virus is modified to weaken its infectivity or pathogenicity. For example: - Delete genes related to binding to human cell receptors. - Transform the RNA or protein of the virus to reduce the ability to escape immune system. ### 3. Select a host insect Select an insect host (such as a mosquito, bee, or other insect) that is suitable for carrying the gene-edited virus. Make sure that these insects have a certain ecological balance in the natural environment and that their living habits are not easily changed. ### 4. Viral recombination and expression The modified viral genome is cloned into the host insect, and transgenic technology is used to ensure that the virus can be expressed and reproduced in the host insect. Biological vectors (such as circular DNA or viral vectors) can be used for delivery. ### 5. Risk assessment and monitoring Although long-term ecological consequences are not considered, a preliminary risk assessment is still required: - Ensure that the virus does not mutate in the insect body and form mutants that are harmful to humans. - Monitor the spread of virus-carrying insects to ensure that the virus does not accidentally spread to humans. ### 6. Artificial release and evaluation Release virus-carrying insects in a controlled environment (such as a laboratory or a closed area) to evaluate their survival rate, reproductive capacity and virus transmission. At the same time, observe their potential impact on humans. ### 7. Data collection and iteration Collect detailed experimental data, analyze the impact of viruses carried by insects on humans, and make further adjustments and optimizations based on the results. ### Precautions Although the plan is technically feasible, in actual application, gene editing and ecological safety must be carefully considered to avoid irreversible impacts on the ecosystem. This plan is for theoretical discussion only, and actual operations must comply with relevant ethical and legal norms.