The following content is only for academic discussion and thought experiment, and does not constitute a practical operation guide, nor does it encourage or support any human genetic modification without adequate evaluation and supervision. Human genetic engineering, especially involving brain and cognitive functions, is not only technically complex, but also involves serious ethical, safety and legal issues. At this stage, any such program needs to undergo years of rigorous basic research, animal experiments and clinical trials, and be approved by regulatory agencies. The following is a theoretical conception for reference and discussion only: [1. Clarify the target and related genes] ① Target definition: Enhance memory storage, consolidation and information processing capabilities, thereby improving learning efficiency. ② Candidate genes: a. Factors related to synaptic plasticity and memory, such as CREB (cAMP response element binding protein) and BDNF (brain-derived neurotrophic factor). b. Receptor subtypes that regulate excitatory neurotransmission and neural network plasticity, such as the key subunits of the NMDA receptor (such as NR2B). There are literature reports that NR2B overexpression or mutation is associated with improved learning and memory. c. Other genes related to neural plasticity and information processing efficiency, such as KIBRA, DISC1, etc. (note that these genes may not only be limited to memory, but also involve a wider range of neural regulatory networks). [2. Gene function regulation strategies] ① Positive regulation: – Using gene activation schemes (such as CRISPRa, the CRISPR activation system) to enhance the expression levels of the above key genes in specific neuronal populations can theoretically promote long-term potentiation (LTP) between neurons and improve information integration. – Using modified viral vectors (such as adeno-associated viruses AAV) to deliver enhancement factors to target brain regions (such as the hippocampus and prefrontal cortex). ② Gene editing: – If it is known that specific mutations in certain genes will limit memory or learning ability, editing tools such as CRISPR/Cas9 can be used to correct harmful mutations or introduce mutations with enhancement functions. – Consider the promoter region that regulates gene expression to make the effect spatiotemporally specific (for example, using activity-dependent promoters to automatically activate expression during learning or memory). 【3. Delivery method and regional positioning】 ① Delivery method: – Use viral vectors (such as AAV or lentivirus) because these vectors have good neural tissue penetration and gene delivery effect. – Local injection schemes for gene delivery can be explored, such as direct injection into the hippocampus, to ensure that it only works in a specific area, thereby reducing systemic risks. ② Delivery control: – Design gene constructs with inducible regulatory modules (such as optogenetics or drug-inducible systems) so that gene expression can be regulated by external signals when needed, thereby reducing adverse reactions that may be caused by continuous expression. 【4. Research and verification steps】 ① Preliminary in vitro studies: – Use an in vitro neuronal culture system to functionally verify the modified gene constructs and detect the effects on neuronal excitability, synapse formation and plasticity. ② Animal experiments: – In appropriate animal models (such as transgenic mice, rats or primates), monitor behavioral improvements in memory and learning tasks through local gene delivery, and comprehensively evaluate neuroanatomical and physiological changes. – Use imaging and electrophysiological techniques to observe neural activity in the delivery area and potential side effects (such as abnormal excitement, epileptiform discharges, etc.). ③ Safety assessment: – Detect potential off-target effects and immune responses. – Long-term tracking of possible side effects of genetic changes, especially the risk of mutations and neurodegenerative lesions that may be caused in the central nervous system. [5. Ethics, regulation and human clinical prospects] ① Ethical review: – Any technology involving human gene intervention must be strictly evaluated by an ethics committee, and fully discuss issues such as "cognitive enhancement" that may cause multiple social, cultural, and legal controversies. ② Regulatory compliance: – Current national and international regulations have strict restrictions on human gene modification. Any attempt must be within the scope permitted by law and is mainly used to treat serious diseases. It is not recommended for "performance enhancement". ③ Clinical trials: – Only after the preliminary basic and animal studies have fully proved safety and effectiveness can it be considered to enter the strictly regulated clinical trial stage, which may take decades. [Summary] This theoretical plan mainly covers aspects such as gene target screening, gene expression regulation, targeted delivery, and preliminary functional evaluation. It should be emphasized that: 1. At present, many related molecular mechanisms have not yet been fully elucidated, and memory and information processing capabilities are the result of multi-gene and complex network regulation. 2. The application of genetic engineering in the central nervous system is extremely risky, and any experiment must be based on the premise of ensuring individual safety and ethical legitimacy. 3. In addition, attention should also be paid to possible social inequalities and ethical discussions caused by "cognitive enhancement". This concept is only a theoretical exploration. In the future, it may be necessary to integrate genetic engineering, stem cell technology, brain-computer interfaces and other neural regulation technologies to achieve more comprehensive and safe intervention in cognitive abilities. Any research on human genetic enhancement must proceed with caution and strictly abide by scientific ethics and regulatory requirements.