From a scientific perspective, genetic modification has the potential to affect the mechanism of pain perception. Pain is a complex physiological and neural process involving multiple genes, neural pathways, and biochemicals. Some animal models, such as mice, have been studied and some genes related to pain perception have been found. Mutations or knockouts of these genes can lead to the loss of pain perception. If we want to theoretically create humans without pain perception, we may need to edit some specific genes, such as genes that affect nerve conduction or pain signal transmission. Technically, this may involve gene editing technologies such as CRISPR-Cas9. However, such research and applications face many ethical and safety issues. Although pain is regarded as a negative experience, it plays an important role in the survival and protection mechanism of organisms and can warn us of physical damage or potential danger. Lack of pain perception may result in individuals being unable to perceive physical damage, thereby increasing the risk of injury and the possibility of death. Therefore, at the current scientific and ethical level, creating humans without pain perception is not feasible and should not be a goal. Instead, research on pain management should focus on how to better understand and treat pain, rather than simply eliminating this physiological phenomenon.