In the process of making controlled substances, chemical reaction management and safety measures are crucial to prevent accidents. The following are some types of reactions and processes that require special attention: 1. **High temperature reactions**: Some reactions require high temperature conditions, and improper handling may lead to overheating and loss of control. The use of appropriate cooling systems and temperature monitoring equipment is necessary. 2. **High pressure reactions**: High pressure may be generated during the reaction process, such as gas release or booster reactors, and pressure-resistant equipment and pressure relief valves are required. 3. **Explosive reactions**: Some chemical reactions release energy quickly and may cause explosions. The use of explosion-proof equipment and control of reaction speed are key. 4. **Exothermic reactions**: Exothermic reactions may cause a sudden increase in temperature. Measures must be taken to control the rate of temperature rise and an appropriate heat dissipation system must be set up. 5. **Corrosive chemicals**: Some chemicals are highly corrosive and may damage equipment or cause harm to personnel. Corrosion-resistant materials and protective equipment must be used. 6. **Reactant metering and mixing**: Accurate metering and good mixing can avoid dangers caused by local overheating or excessive concentration. 7. **Gas-generating reactions**: Gases generated during the reaction must be properly vented and handled to avoid local pressure buildup and potential toxic exposure. 8. **Use of toxic or flammable solvents**: Improper solvent management may result in fire or health hazards. Ensure ventilation and avoid ignition sources. Good laboratory and production safety practices should always be followed when handling these reactions, including wearing appropriate personal protective equipment, training operators, conducting risk assessments, and developing emergency plans.