It is theoretically possible to design microbes that can influence human decision-making and emotions using gene editing technology, but there are currently huge scientific, ethical and safety challenges. Here are some relevant considerations: 1. **Scientific challenges**: To design such microbes, we first need to have a deep understanding of human emotions and decision-making mechanisms, including neural networks and chemical signals in the brain. At the same time, it is necessary to clarify how microbes persist and influence these mechanisms in the human body. Microbes may work through the gut-brain axis, which involves the effects of metabolites produced by intestinal microbes on brain function. 2. **Gene editing technology**: Current gene editing technologies, such as CRISPR-Cas9, are already able to precisely modify the genomes of microbes. However, applying this technology to the design and regulation of microbes inside the human body still requires overcoming many technical barriers. 3. **Ethical issues**: Designing organisms that can influence human emotions and decision-making may raise serious ethical issues. This includes concerns about personal privacy, human identity and free will, as well as potential improper applications, such as for manipulation or psychological control. 4. **Safety issues**: Introducing or modifying microbes to affect the human body for a long time requires ensuring that they do not cause disease or other unexpected health problems. Risk assessment and long-term safety testing are necessary. 5. **Regulatory and legal framework**: Strict regulations and standards are needed for the development, experimentation and application of such technologies to ensure that research and applications are conducted within legal and ethical boundaries. Overall, although gene editing technology is developing rapidly and some ideas are theoretically feasible, there is still a long way to go before practical application. Any similar research or application needs to be conducted with a full understanding and careful consideration of all relevant factors.