Using gene editing technology to enhance human adaptability to high-radiation environments is a cutting-edge and complex field that involves multidisciplinary collaboration, including genomics, molecular biology, radiobiology, and medicine. Here are some potential approaches and considerations: 1. **Enhanced DNA repair mechanism**: Radiation can cause DNA damage, so enhancing the DNA repair ability of cells is a key strategy. Gene editing technologies, such as CRISPR-Cas9, can be used to enhance the function of related genes, such as P53, ATM, BRCA1/2, and other genes involved in DNA repair. 2. **Enhanced antioxidant defense**: Radiation produces a large amount of reactive oxygen species (ROS), which causes cell damage. Gene editing can enhance the expression of genes related to antioxidants, such as SOD1, CAT, GPX, etc., to improve the ability of cells to scavenge free radicals. 3. **Reference to radiation-resistant biological models**: Studies have found that some extremely radiation-resistant organisms, such as actinomycetes (such as "extreme glial bacteria"), have strong DNA repair and antioxidant abilities. Scientists may identify key genes through the study of the genomes of these organisms and try to make similar genetic adjustments in humans. 4. **Immune system enhancement**: Radiation weakens the immune system. Enhancing the function of immune-related genes through gene editing can help maintain the robustness of immune function. 5. **Metabolic adjustment**: Adjust genes related to metabolism to reduce radiation-induced metabolic disorders. For example, certain metabolic pathways can be enhanced to optimize energy utilization and reduce radiation damage. 6. **Regulation of the expression of survival proteins**: Certain proteins such as heat shock proteins can help cells survive under stress conditions and better fold and repair damaged proteins. However, factors that need to be considered in implementing these strategies include: - **Safety and ethics**: Gene editing, especially in germ cells or embryos, faces huge ethical controversies and safety risks. - **Targeted precision**: Ensure the accuracy of gene editing to avoid potential side effects or diseases caused by unexpected or off-target effects. - **Long-term effect research**: In-depth study of the long-term effects of modified genes in multiple generations. - **Interdisciplinary collaboration**: Extensive collaboration from biologists, medicinal chemists, ethicists and policymakers is required. In summary, although gene editing has the potential to help improve human survival in high-radiation environments, research in this field is still in its early stages and it will take some time before it can be put into practical use.