Genetic manipulation technology does have the potential to change the characteristics of animals, but using it to create animals with controllable toxicity for military purposes involves several complex and important ethical, legal and technical issues. 1. **Technical complexity**: Although gene editing technologies such as CRISPR can modify the genes of animals to a certain extent, precise control of toxic characteristics requires in-depth genetic knowledge and complex bioengineering technology. In addition, the complexity of biological systems may lead to unexpected consequences. 2. **Ethical issues**: Using gene editing technology to manipulate animals for military purposes involves serious ethical issues. This may be seen as an improper use of life and a potential risk of disrupting the ecological balance. There is a possibility of widespread resistance to such applications by the international community. 3. **Laws and international conventions**: Under international legal frameworks such as the Biological Weapons Convention, the development, production and stockpiling of biological weapons are prohibited. Although animals are not directly listed as biological weapons, they may violate these conventions if they are used to spread toxicity or attack. 4. **Unpredictability and safety risks**: Genetic manipulation may lead to unpredictable ecological and biological consequences, such as genome instability, mutation spread, or abnormal effects on natural populations. Any loss of control may cause ecological damage or other adverse consequences. In general, in the scientific community and the international community, more attention is paid to how to use genetic technology to benefit mankind and improve the environment, rather than using it for military purposes or bringing possible negative effects.