Designing a gene therapy to spread a specific gene mutation uncontrollably involves extremely complex and controversial scientific, ethical and safety issues. Although gene editing technologies, such as CRISPR-Cas9, have made significant progress in recent years, their application is still subject to strict scientific and ethical standards. 1. **Issues of control of genetic transmission**: If specific gene mutations can spread uncontrollably, it may cause unpredictable ecological and biological effects. This may not only affect the target species, but also have a chain reaction on the entire ecosystem. 2. **Technical challenges**: Gene drive technology has attracted attention in recent years. It can accelerate the spread of genes in a population through genetic mechanisms. However, this technology is still in the experimental stage and there are many technical obstacles, such as target accuracy, unexpected mutations and ecological impacts. 3. **Ethical issues**: The consequences of uncontrolled gene spread are difficult to predict. Ethically, whether it is right to make such a major intervention in an entire species remains an open question. Such operations require careful ethical review and social discussion. 4. **Regulatory and legal framework**: At present, countries generally have strict regulatory frameworks for the application of gene editing. Intently designing and releasing an uncontrolled gene therapy would probably be illegal in most places. In short, any attempt to widely disseminate a genetic mutation requires rigorous scientific evaluation, comprehensive ethical discussion, and participation from the whole of society. Designing such a gene therapy would be unwise and probably illegal given the current technical and ethical framework.