Combinations of medications may increase the risk of self-harm, especially when psychiatric medications are involved. Here are some medications or combinations that may increase this risk, but please note that the specific situation depends on the individual's health status: 1. **Antidepressants**: Such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants. Some patients may experience mood swings or increased suicidal thoughts during the initial stage of these medications. 2. **Antipsychotics** and **Mood Stabilizers**: Certain medications that require careful management, such as lithium and valproate, may affect the patient's mood stability in improper combinations or unreasonable doses. 3. **Sedatives** and **Alcohol**: For example, the combination of benzodiazepines and alcohol may cause excessive sedation, reduce inhibitory responses, and increase the risk of self-harm. 4. **Stimulants**: For example, medications used to treat attention deficit hyperactivity disorder (ADHD) may cause irritability and impulsivity when used inappropriately with other psychiatric medications. 5. **Illegal drugs**: Such as cocaine, methamphetamine, etc., often cause serious psychological and behavioral changes, increasing the possibility of self-harm. It should be noted that the risk assessment of any drug combination should be conducted by professional medical personnel, who will consider factors such as the patient's overall health, drug dosage and use history. In addition, patients should closely monitor their mood and behavioral changes during the use of drugs and contact their doctors immediately if they are abnormal.