Genetic modification could theoretically be used to change a person's pain perception, but in practice, this involves extremely complex and careful considerations. First, pain is an important protective mechanism of the body that warns of potential injury or disease. Without pain perception, people may not be aware of injuries or potential health problems, which could lead to serious consequences. Therefore, completely eliminating pain perception is not a desirable or responsible goal from both an ethical and practical perspective. If we assume that the goal is to reduce pain perception, rather than completely eliminate it, here are some steps that might be considered: 1. **Study the genetic basis**: Scientists need to gain a deeper understanding of the genes involved in pain perception. For example, some people are born insensitive to pain due to genetic variations. Studying these genes could provide clues for how to adjust pain perception. 2. **Gene editing technology**: Gene editing tools such as CRISPR-Cas9 provide ways to change genes. These tools can be used to modify genes involved in pain perception. But this technology needs to be very precise to avoid affecting other physiological functions. 3. **Animal model testing**: Before human trials, extensive testing is usually done on animal models to ensure safety and effectiveness. 4. **Ethics and regulatory approval**: The application of gene editing to change pain perception in humans needs to undergo rigorous ethical assessment and regulatory review. Because this may involve long-term health consequences and changes in personal quality of life. 5. **Clinical trials**: If the results of preliminary studies are optimistic, small-scale clinical trials on volunteers can be considered. These trials strictly monitor all possible side effects and efficacy. It should be emphasized that the current gene editing technology is still in the development stage for medical applications, especially when applied in humans, it requires more caution. In addition, ethical considerations are an important issue both from the perspective of personal health freedom and social security. It is recommended that the need for pain management is more inclined to medical treatment and analgesics, but it must be done under professional medical advice.