The following are some drug categories and examples that may change their effects (usually enhancing the drug's effects and other adverse effects) when mixed with grapefruit juice: **1. Statins** - such as simvastatin, atorvastatin, etc. The ingredients in grapefruit juice inhibit the enzymes in the intestines that metabolize these statins, resulting in increased drug concentrations in the body and increased risk of adverse reactions, such as muscle pain and liver damage. **2. Calcium channel blockers** - such as nifedipine, amlodipine, etc. They can increase drug absorption and blood drug concentrations, which may cause adverse reactions such as low blood pressure, dizziness, and palpitations. **3. Certain antiarrhythmic drugs** - such as amiodarone, etc. Interactions with grapefruit juice may affect drug metabolism and change its effects and safety in the body. **4. Some immunosuppressants** - such as cyclosporine. They interfere with the normal metabolic process of drugs, causing the drugs to accumulate in the body and increasing the chance of adverse reactions such as nephrotoxicity. It should be emphasized that patients should avoid drinking grapefruit juice at will while taking any medication. If they need to know the specific interactions between drugs and food, they should consult a doctor or pharmacist.