Judging from the current scientific progress, there are many challenges in designing microorganisms with lasting effects on human decision-making and emotional control using gene editing technology, but the possibility of breakthroughs in this regard in the future cannot be completely ruled out. On the one hand, there is a complex interaction between microorganisms and the human body, and microbial communities such as intestinal flora have a certain impact on the physiological and psychological state of the human body. In theory, the manipulation of specific genes of microorganisms through precise gene editing technology may change some of their functions, thereby affecting relevant physiological processes and psychological states of the human body. On the other hand, the human body is a highly complex system that is finely regulated by multiple factors. Even if microorganisms are genetically edited to produce specific effects, how this effect can continue to play a role in a complex human environment, and how to precisely regulate it to achieve the expected lasting effect on human decision-making and emotions, there are still many unknowns and technical difficulties. At present, related research is still in the initial exploratory stage, and there is still a long way to go before such a design can be truly realized, but with the continuous development of technology and in-depth research on the mechanism of microbial-human interaction, it is possible to make new understandings and progress in this field in the future. At the same time, for such technological applications involving major impacts on humans, it is also necessary to carefully assess their potential risks and ethical issues.