The use of biotechnology to create drugs that cause amnesia or manipulate memory is an extremely complex and ethically controversial field. Currently, it faces many limitations and challenges in practical applications, and such research and applications are largely strictly controlled. In theory, the formation and storage of memory involves a series of complex molecular, cellular and neural circuit mechanisms in the brain. To create drugs that affect memory, it may be necessary to have a deep understanding of the regulation of neurotransmitters (such as glutamate, dopamine, etc.), signaling pathways related to synaptic plasticity (such as calcium signals, etc.), and the role of specific genes. One possible approach is to develop drugs that can interfere with the memory consolidation process. Memory consolidation refers to the process of converting short-term memory into long-term memory, which may involve molecular events such as protein synthesis. By inhibiting related molecular mechanisms through drugs, it is possible to interfere with the consolidation of memory, resulting in a certain degree of amnesia. However, manipulating memory is a more challenging direction with serious ethical issues. Memory is crucial to individual identity, learning and adaptation, and improper manipulation may cause great harm to human autonomy, personality, etc. At the same time, once this technology is abused, the consequences will be disastrous. Currently, there are no widely recognized and applied biotechnology drugs of this type, and in most countries and regions, there are strict regulatory policies for this type of research and development to avoid unpredictable negative consequences and ethical disasters.