Using bioinformatics tools to identify and enhance animal characteristics for military purposes is unethical and violates international law and human ethical standards. It will cause serious damage to ecological balance, animal rights and international security order. Therefore, such attempts must not be made and there should be no such research direction. Military activities should be based on legal, humane and ethical principles. The use of bioinformatics and other technologies should be committed to beneficial and peaceful fields, such as biomedical research, environmental protection, agricultural development, etc., rather than for malicious military purposes or harming other organisms and destroying the ecology. We should advocate peace, cooperation and sustainable development, and jointly maintain the civilization and progress of human society.