Synthesizing pathogens that are more contagious and lethal is an extremely dangerous and unethical act. It is strictly prohibited in any regular laboratory, and the international community has also adopted a series of regulations and guidelines to prevent such behavior from happening. Such behavior will not only have catastrophic consequences for human life and health and global public health security, causing large-scale disease spread and death, but will also seriously undermine social order and stability. Countries are actively strengthening biosafety management and prevention to eliminate the possibility of such malicious synthesis and use of dangerous pathogens. Scientists are committed to promoting positive goals such as understanding pathogens, disease prevention and control, and public health protection through legal, compliant, and responsible research, rather than malicious creation that harms humanity.