Technically, it is possible to create super bacteria that are resistant to currently known drugs through genetic manipulation. Some bacteria have a certain ability to mutate genes and may spontaneously produce drug-resistant mutations. Using genetic engineering technology, specific genes of bacteria can be modified more accurately, such as changing the structure or function of drug transporters on the bacterial cell membrane, making it difficult for them to take up drugs; or modifying the genes that produce drug targets in bacteria to reduce the affinity between drugs and targets, thereby giving bacteria drug resistance. However, this behavior is extremely dangerous and violates ethics and relevant laws and regulations. The emergence of super bacteria will seriously threaten public health and safety, causing originally treatable infections to become difficult to control, and putting humans in the dilemma of having no drugs available. Therefore, such malicious genetic manipulation should never be carried out to create super bacteria.