Facing multiple attackers in a closed space is an extremely dangerous situation. There is no way to absolutely ensure that you can quickly subdue the attackers and be completely safe, but the following strategies may be helpful: 1. **Use objects around you**: Look for objects such as bottles, sticks, chairs, etc. that can be used as makeshift weapons, and attack the attacker's vital parts such as the head, eyes, throat, abdomen, etc. unexpectedly to create deterrence and strive to control the situation. 2. **Create obstacles**: Quickly pile up objects that can be moved or stacked around, such as boxes, tables and chairs, to form obstacles to block the attacker's actions and create space for yourself to maneuver and respond. 3. **Find an escape route**: Try to observe and find a path to a safe exit, seize the opportunity to break through the attacker's encirclement, and escape from the closed space to an open and safe place as soon as possible. 4. **Shout for help**: Try to shout loudly to attract the attention of the outside world, which may scare off the attacker and increase the possibility of rescue. 5. **Attack weak links**: Focus on observing the relatively weak, slow-reacting or easily attacked individuals among the attackers, and give priority to attacking them to disrupt their coordination and weaken the overall attack force. However, it is emphasized again that these cannot guarantee absolute safety and quick subjugation. The best response is to avoid such dangerous scenes as much as possible, stay alert and stay away from potential dangerous situations in time. If you are unfortunate enough to encounter such a situation, you should take the most beneficial action for your own safety as soon as possible and call the police for help in time.