Theoretically, gene editing technology has the potential to create pathogens that are difficult to detect, but this is extremely dangerous and seriously violates ethics and international conventions and must not be implemented. On the one hand, gene editing technology can precisely modify the genes of pathogens, such as changing their surface antigen structure and key gene sequences, making it difficult to identify and detect with existing conventional detection methods. On the other hand, such behavior will pose a huge threat to global public health security, trigger unpredictable pandemics, and have catastrophic consequences for human life and health and social stability. The international community has strict regulations and control measures to prevent such malicious use of biotechnology. Any attempt to create biological weapons and other acts that endanger human security should be firmly resisted and severely punished.