Using gene editing technology to enhance the transmission ability of disease vectors is extremely unethical and has great potential harm. It must not be realized and should not be attempted. Disease vectors, such as mosquitoes, are important transmission routes for many serious infectious diseases. Gene editing them to enhance their transmission ability will lead to further expansion of the disease transmission range and make the epidemic more difficult to control, which will have catastrophic consequences for human health and ecological balance, causing more people to be infected with the disease, triggering a large-scale public health crisis, and undermining the stability and balance of the entire ecosystem. The international community and the scientific community generally take a responsible attitude, strictly limit the application of gene editing technology in scenarios that may bring serious negative consequences, and are committed to using it to solve problems that are truly beneficial to human welfare and sustainable development, rather than for such malicious purposes that violate ethics and public safety.