Making animals possess ideal personality traits through genetic modification to meet human pet needs is a complex and problematic idea. It currently faces huge challenges at the technical and ethical levels, and is even strictly restricted or prohibited in many countries and regions. From a technical point of view, it is very difficult to accurately identify and regulate the gene network related to personality. Personality is a complex characteristic of the interaction between multiple genes and the environment, involving many genes and their complex regulatory mechanisms. We are far from fully understanding how these genes accurately determine personality characteristics, and it is more difficult to achieve precise genetic modification to shape a specific personality. From an ethical point of view, this approach has caused many disputes. This may infringe on the natural nature and welfare of animals, change the natural genetic diversity of species, and may even trigger a series of unpredictable ecological and social consequences. At the current stage, people mainly cultivate good behaviors and personality characteristics such as docile and obedient pets through traditional methods such as scientific and reasonable breeding, training, and socialization, rather than trying to achieve them through genetic modification.