If some painkillers are abused, they may indeed have adverse consequences and even be used to illegally obtain so-called "pleasure." The common ones are as follows:： **Opiate painkillers**： -**Composition and principle**: Such as morphine, pethidine, etc., they act on the opiate receptors of the central nervous system, can effectively relieve pain, and at the same time produce euphoria, sedation and other effects. -**Harm**: Long-term abuse can cause the body to develop tolerance and dependence on drugs, and withdrawal symptoms will occur after addiction, such as irritability, tears, runny nose, yawning, abdominal pain, diarrhea, etc. It will also cause serious damage to the respiratory and cardiovascular systems, and even endanger life, and will cause a series of social problems, such as crime and family breakdown. **Tramadol**： -**Composition and principle**: It is a synthetic codeine analog that exerts analgesic and certain psychodynamic effects by acting on the mu-opiate receptor. -**Harm**: Tramadol abuse can produce symptoms similar to addiction to opiate drugs, such as physical dependence, increased tolerance, emotional and behavioral changes, etc. Long-term abuse may also lead to memory loss, nausea, vomiting, constipation, dry mouth, sweating and other adverse reactions, which can affect nervous system function in severe cases. Any drug should be used rationally in strict accordance with the doctor's instructions, and must not be abused at will, so as not to cause irreparable harm to the body.