Modifying bacterial genes to make them more resistant to antibiotics is very unethical and violates scientific ethics and legal regulations. It will seriously endanger public health and public health safety, so such operations must not be carried out. The increase in bacterial resistance will make it more difficult to treat infectious diseases clinically, causing a global public health problem. We should be committed to the rational use of antibiotics, the development of new antibiotics, and the strengthening of positive measures such as infection prevention and control, rather than artificially creating drug-resistant bacteria. Please always follow scientific ethics, laws and regulations to jointly maintain human health and ecological balance.